Palpatine mentioned in “Empires End” that he was sensing an unknown dark side presence that lied somewhere within the Unknown Regions (Most likely Exegol but that has yet to be confirmed).
However, he also mentioned that the Unknown Regions was barred from the known galaxy by a labyrinth of Solar Storms, Black Holes, Rogue Magnetospheres, and other hyperspace anomalies making navigation nearly impossible.
Not to mention, Palpatine was informed by the Chiss, Thrawn that evil threats such as nomadic pirates and other hostile alien races, were known to frequent this area of space (Possibly the Grysk or Vagaari Empire).
Following Palpatine’s death, many loyal imperials were given instructions to rendezvous with Palpatine’s Flag ship, the Eclipse and enter the unknown regions using coordinates extracted by his observatories which had found safe passage.
One of the imperials, Rey Sloan described having to navigate through Superstorms for months. She also mentioned encountering other anomalous activity within her voyage such as magnetic bursts of energy that caused temporary engine failures and witnesed unidentified creatures in the void (Possibly Summa Verminoths or Purrgils)
Those descriptions heavily match the information regarding the Red Honeycomb Zone which was mentioned by Rose Tico in the “Rise of Skywalker” to be a collection of superstorms and anomalies near the planet Exegol.
Even Kyo Ren and Rey had to navigate through the anomaly just to reach the Sith Planet.
So is it meant to be the same anomaly mentioned in other canon material? “The Rise of Skywalker” isn’t really my favorite Star Wars movie but this was one of the portions of Canon that generally fascinated me.