I just finished the last episode of the Big Bang Theory. It has definitely been one of my favorite sitcoms, (I suspect I may have enjoyed it more than most because I have a degree in Physics....). The show was great and had a great ending. However, at the risk of screwing up a show's great ending, I would love to see a new series based on this one. The show I would suggest would be a bit more wild than the original, despite having all the same characters.
In this new show, Sheldon and Leonard would make yet another breatk through, with the help of the others. This new break-through would be faster than light travel and communicaton, (using very common and cheap materials). As the military again threatens to take their discovery and exclude them, this time they realize that they could actually just build their own cheap, low-end ship and live out their Star Trek / Star Wars fantasies exploring the universe and making new and amazing discoveries. As, the ship's navigation and operation require extremely complex calculations to run, Shedlon is the only one capable of actually running the ship, thus once more making him the central controlling figure in his group of friends. As everyone now has familiies, Stuart is taken with and giving the rank of "Ship's Nanny". Perhaps Kripke could even sneak on board as a semi-villainous character (similar to Dr. Smith from Lost in Space).