She would take away his computer, his books and make sure he watches no TV, not even Star Trek for about 6 weeks. And he is made to do chores all day and he would have a worse punishment in any way he wants if she disobeyed ... and it would be a karma for him and Mary for their actions in Season 6 in the episode "A German Folk Song and an Actual Adult" where I also hope Missy was able to get Georgie a gift for his birthday since it would mean trouble for George, Mary and Sheldon, especially the latter two.
And George, Georgie, Meemaw and Mandy agree with how Missy punishes Sheldon.
I also wish Missy would take away Mary's Bible and forbid her to talk about God or religion. She would also punish Mary by taking away her telling her no religious talk and tell Pastor Jeff to keep her out of the church as punishment for neglect.
I wish Missy had control over Sheldon and Mary for the remainder of Season 6 and the whole of Season 7. They both need to be punished for horrible behaviour. And Missy deserves to punish her mother and Sheldon for their actions towards her in the Season 4 finale! I wish Meemaw and George both slapped Mary and Sheldon in that finale!